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B821 Diagnostic Radiography Question: The following four items [characterised in brackets] can be used to construct an argument in support of a biomedical hypothesis in Alzheimer’s disease:  Degenerated and healthy neurons in brains of Alzheimer’s mice‘Neurons progressively degenerate in Alzheimer patients’Electron micrograph (EM) of brain of Alzheimer’s mouse ‘EM pictures of brains of Alzheimer’s mice show dark (often irregularly shaped) and light (often circularly shaped) areas’ a) Which of the four items is the main biomedical hypothesis in this example?b) List the four items in a new order that makes an argument in support of the main biomedical hypothesis. Draw one arrow between each pair of items and label the arrow with either ‘causes’ or ‘provides evidence for’ to show how the two items are related. Answer: a) In the given example, there are two claims or propositions. However, the main biomedical hypothesis is as indicated below. ‘Neurons progressively degenerate in Alzheimer patients’ The above is a biomedical hypothesis which can be verified with further testing. b) In the given case, it is apparent that the evidence for the claim that neurons tend to degenerate progressively with regards to Alzheimer patients is provided by EM of brain of mouse suffering from Alzheimer. The respective diagrams indicating the relationship between the various statements provided in the example are listed below.

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