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DRWA 8000 Doctoral Writing Assessment Question: DHA Doctoral Study Promise Review the DHA definition document “premise cannot be medical or public health”. It has to be a DHA topic. It is going to be on “Gout”. Answer: Premise: Do lifestyle and dietary changes help in reducing the prevalence of gout among middle aged men? Problem Statement Gout is a kind of arthritis, usually manifested by inflammation of the joints that is caused due to excess deposition of uric acid crystals. Men outnumber women in the prevalence of gout symptoms (Kuo et al., 2015). Recent evidences suggest that lifestyle and dietary patterns also play an essential role in increasing the likelihood of suffering from painful gout attacks. However, not many studies have been conducted to determine the effectiveness of changes in dietary patterns and lifestyle modifications for management of gout (Smith et al., 2014). Therefore, this study aims to investigate whether adoption of simple lifestyle changes and a healthy diet reduces the prevalence of gout among middle aged men. Research Question(S) What are the harms and benefits of diet therapy (low protein diet) on the long term health outcomes of men suffering from gout? What are the harms and benefits of lifestyle modifications (regular exercise, maintaining body weight, and hydration) on the long term health outcomes of men suffering from gout? Approach For The Study 300 men, aged more than 35 years suffering from gout will be selected from 6 hospitals across the district, after confirmation of their symptoms from the corresponding rheumatologists. 150 of them will be randomly recruited to the sample group that will receive the intervention, and the rest 150 will form the control. The sample group will be made to follow a low calorie diet. Limit will be imposed on the intake of proteins, seafood, meat, white flour, high fat products, sugar and alcohol (Torralba, Jesus & Rachabattula, 2012). In addition, they will be made to exercise daily for 40 minutes to reduce weight and consume at least 10 glasses of water per day (Moi et al., 2014). The interventions will be applied for 4 months and a 3 month follow-up period will be maintained. The sample and the control group will be given questionnaires to analyze their knowledge on the disease and the immediate benefits or harms they are observing with or without the intervention.  A statistical analysis of the responses using the SPSS 21.0 software will provide an idea on the probable benefits or harms of the dietary and lifestyle changes. Possible Secondary Data Types Or Sources Of Information Secondary data sources will include the following: Agency for Healthcare Research and Quality The WHO Global InfoBase Data Warehouse Men’s Health Study—Nutrition and health and disease investigation collecting data on males National Health Care Surveys These secondary sources will provide information on the etiology, risk factors and management of gout. References Kuo, C. F., Grainge, M. J., Zhang, W., & Doherty, M. (2015). Global epidemiology of gout: prevalence, incidence and risk factors. Nature reviews rheumatology, 11(11), 649-662. Moi, J. H., Sriranganathan, M. K., Falzon, L., Edwards, C. J., van der Heijde, D. M., & Buchbinder, R. (2014). Lifestyle interventions for the treatment of gout: a summary of 2 Cochrane systematic reviews. The Journal of Rheumatology Supplement, 92, 26-32. Smith, E., Hoy, D., Cross, M., Merriman, T. R., Vos, T., Buchbinder, R., … & March, L. (2014). The global burden of gout: estimates from the Global Burden of Disease 2010 study. Annals of the rheumatic diseases, 73(8), 1470-1476. Torralba, K. D., Jesus, E., & Rachabattula, S. (2012). The interplay between diet, urate transporters and the risk for gout and hyperuricemia: current and future directions. International journal of rheumatic diseases, 15(6), 499-506.

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