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PHAR 621 Pharmacy Law And Ethics

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PHAR 621 Pharmacy Law And Ethics Question Read and expalin the article of New Prescription Drugs: A Major Health Risk With Few Offsetting Advantages the article by Donald W. Light. Answer There are a few new drugs that caused serious reaction after getting approval.  So, physicians recommended not to consume a drug at least after 5 years of patient trial. However, almost 1.9 million hospitalization in a year occurred even after properly prescribed drug consumption. 2.74 million of adverse drug reaction occurred in  total in a year and 128000 people had died by prescribed drug reactions. This causes prescription drugs to be a major cause of health risk and stoke had become 4th leading cause of death. According to report of European commission, adverse drugs from prescription causes almost 328000 patients died in US and Europe in a year. However, FDA acknowledges a few fractions of that cases. Almost 170 million American patients take prescribed drugs and among them 80% is generic. However, patients, who take new patented drugs are, only able to generate modest benefits over old drugs.  A very small number of drugs (11-15%) are capable of giving advantageous effect to the patient over the pre-established drugs. Almost 4/5th of $70 billion was spend on slightly new variation of drugs. In between 2002 to 2011, the researcher of France, the Netherlands and Canada had reported that, 8% of new drugs were effective in nature (Light, 2014). Therapeutically similar drugs had advantages like some patients may respond to a new drugs same class instead of old ones. The main benefit of testing drugs is to identify specific patients who might get benefit from that drug. Most of the significant discoveries resulted in clinical advancement. Silvio Garattini told “When a major discovery actually helps patients, we feel very lucky.” Introducing more number of minor variants of drug is not for the patient advancement and it is just a marketing strategy. Jerry Avon told that laws for meaningful innovation are giving more profit than medical advancement. Marc-Andre Gagnon has shown that net return on revenue has enhanced 2.5 times to 3.2 times due to high price and more prescription by the physicians. The large companies have less risks as they only invest after the people have paid for the high risks of research and they can divide the risks on various projects. In last 35 years, behind every hospitalization there is almost 30 adverse events and 81 million adverse effects are experienced by the Americans. Most of the medical error causes lack in productivity and road accidents. Apart from the ‘R & D pipeline’, trial-journal pipeline is the randomized clinical trials and the commercially funded clinical trials are less effective than non-commercially funded trials. Pharmaceutical companies retain statistical data of the previous drugs and that were submitted to FDA. Marc Rodwin reported that drug firm’s trial results are biased in nature. The twice biased evidences are harming the science. Sergio Sismondo stated a new model that influence physicians to prescribe new patented drugs. New FDA policies results faster response of drug approval and this had enhanced the adverse events by 18%, death rate by 7.2%. The risk has become 1 in 3 after this new policy. Vioxx drug disaster causes 40,000 deaths and a monitoring system has been introduced. However, if FDA would approve drugs with adequate evidences, the condition would improve and FDA can use its power to do so. Bibliography Light, D. (2014). New Prescription Drugs: A Major Health Risk With Few Offsetting Advantages. Available at: [Accessed 17 Dec. 2018].

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